BDBM50346088 (1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid::4-Cyano-3-cyclopentyloxy-4-(4-methoxy-phenyl)-cyclohexanecarboxylic acid::4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid::4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid (Ariflo)::4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid methyl ester::4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid(Ariflo)::6-(3,4-Dimethoxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one::Ariflo::CHEMBL511115::SB-207499
SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
InChI Key InChIKey=CFBUZOUXXHZCFB-OYOVHJISSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 48 hits for monomerid = 50346088
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substratesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substratesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant PDE4B2-mediated cAMP hydrolysis for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 813nMAssay Description:Inhibition of human Phosphodiesterase 4C from peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Inhibition of human Phosphodiesterase 4B from peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human Phosphodiesterase 4D from peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of [3H]rolipram binding in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Tested for its ability to inhibit the hydrolysis of cAMP by human monocyte cytosol phosphodiesteraseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE4 from U937 monocytic cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of PDE4 in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of phosphodiesterase 4 (PDE4) in human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) in cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 3.41E+3nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of PDE4C (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant PDE4B by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma
Curated by ChEMBL
Asahi Kasei Pharma
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 813nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair